The CMB Cold Spot

The CMB (cosmic microwave background) Cold Spot is a region of space that stretches for about 1 billion light years, an humbling 6-10 billion light years away from the Solar System. It is different from other voids in that it is orders of magnitude larger in size and is relatively colder in terms of temperature. CMB stems from the Big Bang, and is present throughout the universe at a temperature of approximately -270.3°C.

What's interesting about this is that there are quite a few anomalies discovered. The Cold Spot, arguably the most puzzling discovery, is about 70*10^-6 K colder than the region of space around it. In contrast, common temperature variations are generally about 18*10^-6 K. Furthermore, the variations in temperature of the Cold Spot extend to about 140*10^-6 K relative to the average temperature of background radiation.

The Cold Spot circled on the lower right in contrast to its surroundings
The presence of cosmic microwave background radiation is yet to be detected, although several theories have been proposed in an effort to explain this anomaly.

Portal to a parallel universe
 
This might seem more like pseudoscience than anything else, but astronomers and researchers alike have stated that a collision between completely different universes could have led to it's formation. They've claimed that their data could prove the existence of parallel universes, or the multiverse theory. Analysis from light spectra from over 7,000 galaxies revealed tiny voids surrounded by galaxy clusters (such as our own Laniakea Supercluster) instead of a massive supervoid.

A significantly more detailed picture of the CMB Cold Spot
Another void between us

Another explanation includes the presence of a different void between Earth and the Cold Spot. It is possible for a region cooler than it's surroundings to be existent  if a large void is present. In other words, a lack of galaxies would mean the spot looks colder than it might be as galaxies appear to make background radiation seem warmer than it actually is.

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